Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.

@article{Ando2005EffectsOG,
  title={Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.},
  author={Hitoshi Ando and Shuichi Tsuruoka and Hayato Yanagihara and Koh-ichi Sugimoto and Masaaki Miyata and Y. Yamazoe and Toshinari Takamura and Shuichi Kaneko and Akio Fujimura},
  journal={British journal of clinical pharmacology},
  year={2005},
  volume={60 5},
  pages={494-7}
}
AIMS To compare the effects of grapefruit juice (GFJ) on the pharmacokinetics of pitavastatin and atorvastatin. METHODS In a randomized, four-phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On each final day, a single dose of 4 mg pitavastatin or 20 mg atorvastatin was administered. RESULTS GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin acid by 13% (-3 to 29%). CONCLUSIONS… CONTINUE READING