Effects of granulocyte-colony stimulating factor after stroke in aged rats.

  title={Effects of granulocyte-colony stimulating factor after stroke in aged rats.},
  author={Aurel Popa-Wagner and Kai St{\"o}cker and Adrian Tudor Balseanu and Andreas Rogalewski and K. -W. Diederich and Jens Minnerup and Claudiu Mărgăritescu and Wolf R{\"u}diger Sch{\"a}bitz},
  volume={41 5},
BACKGROUND AND PURPOSE In aged humans, stroke is a major cause of disability for which no neuroprotective measures are available. Granulocyte-colony stimulating factor (G-CSF), a member of the cytokine family of growth factors, promotes brain neurogenesis and improves functional outcome after stroke in young animals. We tested the hypothesis that G-CSF provides a restorative therapeutic benefit in aged animals. METHODS Focal cerebral ischemia was produced by reversible occlusion of the right… CONTINUE READING


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The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice

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