Effects of granisetron in children undergoing high-dose chemotherapy: a multi-institutional, cross-over study.

@article{Tsuchida1999EffectsOG,
  title={Effects of granisetron in children undergoing high-dose chemotherapy: a multi-institutional, cross-over study.},
  author={Yoshiaki Tsuchida and Yukiko K. Hayashi and Keiko Asami and Keiko Yamamoto and Junichi Yokoyama and Hideo Mugishima and Toshiro Honna and Jun-ichi Mimaya and Fumikata Hara and Tetsuji Sawada and Takeshi Matsumura and Sachiyo Suita and Toshikado Sugimoto and Michio Kaneko},
  journal={International journal of oncology},
  year={1999},
  volume={14 4},
  pages={673-9}
}
The efficacy of granisetron hydrochloride 20 microg/kg and 40 microg/kg were compared using a cross-over method to determine the optimal dose in children with solid tumors receiving high-dose chemotherapy. Granisetron controlled the onset of vomiting in 17 of 23 patients (73.9%) who were given 40 microg/kg of granisetron, while 8 of 21 patients (38.1%) were… CONTINUE READING