Effects of glyphosate exposure on human health: Insights from epidemiological and in vitro studies.

@article{Agostini2020EffectsOG,
  title={Effects of glyphosate exposure on human health: Insights from epidemiological and in vitro studies.},
  author={Lidiane Pignaton Agostini and Raquel Spinass{\'e} Dettogni and Raquel Silva dos Reis and Elaine Stur and Eldam{\'a}ria de V W Dos Santos and Diego do Prado Ventorim and Fernanda Mariano Garcia and Rodolfo C. Cardoso and Jones Bernardes Graceli and I{\'u}ri Drumond Louro},
  journal={The Science of the total environment},
  year={2020},
  volume={705},
  pages={
          135808
        }
}
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A particular focus on glyphosate's potential to induce inflammation, DNA damage and alterations in gene expression profiles as well as adverse effects on reproduction and development is focused on.
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The evidence is sufficient to, under the precautionary principle, define policies to prevent exposure of women, their partners, and their children to glyphosate, and shows strong experimental evidence, in animal models and in vitro studies, of glyphosate toxicity in reproduction and development.
Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity
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Glyphosate Use, Toxicity and Occurrence in Food
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This work aims to review the glyphosate use, toxicity and occurrence in diverse food samples, which, in certain cases, occurs at violative levels.
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Glyphosate-based herbicides: Evidence of immune-endocrine alteration.
Glyphosate and the key characteristics of an endocrine disruptor: A review.
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References

SHOWING 1-10 OF 137 REFERENCES
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination
  • S. Bai, S. Ogbourne
  • Environmental Science
    Environmental Science and Pollution Research
  • 2016
TLDR
Assessment of the health risks associated with glyphosate are more complicated than suggested by acute toxicity data that relate primarily to accidental high-rate exposure.
Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung, and nerve
  • Youwu Hao, Yang Zhang, Liming Tao
  • Chemistry
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
  • 2019
TLDR
The study demonstrates that the toxic effect of GBH is primarily due to the use of formulants, and suggests that GP is relatively safe and a new approach for the assessment of toxicity should be made.
Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines.
Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier.
Cancer Incidence among Glyphosate-Exposed Pesticide Applicators in the Agricultural Health Study
TLDR
Glyphosate exposure was not associated with cancer incidence overall or with most of the cancer subtypes the authors studied, but there was a suggested association with multiple myeloma incidence that should be followed up as more cases occur in the AHS.
Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase
TLDR
It is shown that glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use, and this effect increases with concentration and time, and the presence of Roundup adjuvants enhances glyphosate bioavailability and/or bioaccumulation.
Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity.
Glyphosate Commercial Formulation Causes Cytotoxicity, Oxidative Effects, and Apoptosis on Human Cells
TLDR
The results show that G formulation had toxic effects while no effects were found with acid glyphosate and AMPA treatments, and confirm that G formulations have adjuvants working together with the active ingredient and causing toxic effects that are not seen with Acid glyphosate.
The need for independent research on the health effects of glyphosate-based herbicides
TLDR
The aim of the Ramazzini Institute project is to explore comprehensively the effects of exposures to glyphosate-based herbicides at current real-world levels on several toxicological endpoints, including carcinogenicity, long-term toxicity, neurotoxicity, endocrine disrupting effects, prenatal developmental toxicity, the microbiome and multi-generational effects.
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