Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus


Ivermectin (IVM) is a widely-used anthelmintic that works by binding to and activating glutamate-gated chloride channel receptors (GluClRs) in nematodes. The resulting chloride flux inhibits the pharyngeal muscle cells and motor neurons of nematodes, causing death by paralysis or starvation. IVM resistance is an emerging problem in many pest species… (More)
DOI: 10.1371/journal.ppat.1006663


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