Effects of glucose on receptor-mediated phosphoinositide hydrolysis and second messenger generation in rat glomerular mesangial cells.

Abstract

The phosphoinositide system plays a critical role in mesangial cell contraction. myo-Inositol depletion occurs in glomeruli from diabetic animals and may result in mesangial cell dysfunction. The hypothesis that mesangial cell exposure to high concentrations of glucose could lead to abnormalities in phosphoinositide metabolism and receptor-mediated inositol… (More)

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Cite this paper

@article{Guzman1991EffectsOG, title={Effects of glucose on receptor-mediated phosphoinositide hydrolysis and second messenger generation in rat glomerular mesangial cells.}, author={N. Julia Guzman and Priya A. Kurian and Vincent J Andaloro and Cornelia C Tisher and Fulton Crews}, journal={Journal of the American Society of Nephrology : JASN}, year={1991}, volume={2 2}, pages={179-90} }