Effects of glucosamine infusion on insulin secretion and insulin action in humans.

@article{Monauni2000EffectsOG,
  title={Effects of glucosamine infusion on insulin secretion and insulin action in humans.},
  author={T. Monauni and M. G. Zenti and A. Cretti and M. Daniels and G. Targher and B. Caruso and M. Caputo and D. Mcclain and S. Del Prato and A. Giaccari and M. Muggeo and E. Bonora and R. Bonadonna},
  journal={Diabetes},
  year={2000},
  volume={49 6},
  pages={
          926-35
        }
}
  • T. Monauni, M. G. Zenti, +10 authors R. Bonadonna
  • Published 2000
  • Biology, Medicine
  • Diabetes
  • Glucose toxicity (i.e., glucose-induced reduction in insulin secretion and action) may be mediated by an increased flux through the hexosamine-phosphate pathway. Glucosamine (GlcN) is widely used to accelerate the hexosamine pathway flux, independently of glucose. We tested the hypothesis that GlcN can affect insulin secretion and/or action in humans. In 10 healthy subjects, we sequentially performed an intravenous glucose (plus [2-3H]glucose) tolerance test (IVGTT) and a euglycemic insulin… CONTINUE READING

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