Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells

@article{Wei2009EffectsOG,
  title={Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells},
  author={Peng Wei and Minfeng Shi and Scott Robert Barnum and Hongkwan Cho and Taylor N. Carlson and Jordie D. Fraser},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={2142-2150}
}
Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor that regulates insulin secretion in beta cells. GK activators (GKAs) activate GK via binding to an allosteric site of the enzyme. GKAs increase glucose-stimulated insulin secretion and decrease blood glucose levels. Using the differentiated beta cell line INS-1, we investigated the role of GKAs in promoting beta cell growth and survival and preventing beta cell apoptosis induced by… CONTINUE READING

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