Effects of glucocorticoids on hippocampal long-term potentiation.

  title={Effects of glucocorticoids on hippocampal long-term potentiation.},
  author={Constantine Pavlides and Yoshifumi Watanabe and Bruce S. McEwen},
  volume={3 2},
The effects of chronic and acute corticosterone (CORT) administration were investigated on hippocampal long-term potentiation (LTP) in the dentate gyrus granule cell layer of the rat. Electrophysiological experiments were performed in vivo under urethane anesthesia. Chronic CORT treatment (40 mg/kg/day) over 21 days decreased LTP compared to vehicle controls, even when LTP was measured 48 hours after cessation of CORT treatment, when serum CORT levels had returned to baseline. A single… CONTINUE READING
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