Corpus ID: 55140443

Effects of glucocorticoids in Leishmania major infection

@article{Osero2015EffectsOG,
  title={Effects of glucocorticoids in Leishmania major infection},
  author={Bernard Osero and A. Mosigisi and T. K. Ogeto and R. Mugambi and J. Ingonga and R. Karanja and M. Gicheru and C. Anjili},
  journal={International Journal of Fauna and Biological Studies},
  year={2015},
  volume={2},
  pages={16-22}
}
Leishmania parasites activate NF-κB which induces Th2 expression and inactivates Th1 genes thus subverting the host defense response and promotes the survival and development of the parasite in macrophages. Macrophages were treated artificially with glucocorticoids and incubated with Leishmania promastigotes. Interleukin 1 β, Tumor necrosis factor- α and inhibitory nitric oxide synthase gene levels were measured using real time PCR and parasite development monitored in vitro. Tumor necrosis… Expand

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References

SHOWING 1-10 OF 51 REFERENCES
Cytokines and nitric oxide as effector molecules against parasitic infections.
  • F. Liew, X. Wei, L. Proudfoot
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1997
Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.
Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major
Cytokine‐Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens
Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major
The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.
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