Effects of glucocorticoid on proliferation, differentiation, and glucocorticoid receptor expression in human ovarian carcinoma cell line 3AO.

@article{Xu2002EffectsOG,
  title={Effects of glucocorticoid on proliferation, differentiation, and glucocorticoid receptor expression in human ovarian carcinoma cell line 3AO.},
  author={Ming-juan Xu and Guo-en Fang and Yu-jian Liu and L Song},
  journal={Acta pharmacologica Sinica},
  year={2002},
  volume={23 9},
  pages={819-23}
}
AIM To study the effects of dexamethasone (Dex), a synthetic glucocorticoid, on proliferation, differentiation, glucocorticoid receptor expression and regulation in human ovarian cancer cell line 3AO. METHODS 3AO cells proliferation was evaluated by viable cell count, activity of alkaline phosphatase (AKP) and tumor marker CA125 level were determined; the expression and regulation of glucocorticoid receptor (GR) in 3AO cells was studied with radioligand binding assay. RESULTS Dex inhibited… CONTINUE READING