Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man.

@article{Shalev1997EffectsOG,
  title={Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man.},
  author={Alon Shalev and Jens Juul Holst and Ulrich auf dem Keller},
  journal={European journal of clinical investigation},
  year={1997},
  volume={27 1},
  pages={10-6}
}
The incretin glucagon-like peptide 1 (GLP-1) shows glucose-dependent insulinotropic activity and may exert anabolic effects. Whole-body protein metabolism was assessed by measuring [1-13C]-leucine kinetics in 13 healthy volunteers during hyperglycaemic clamping with or without pancreatic clamping (somatostatin infusion) in order to differentiate between insulin-mediated and direct GLP-1 effects. During intact pancreatic secretion leucine flux and leucine oxidation rate as parameters of whole… CONTINUE READING

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