Effects of glucagon like peptide-1(7-36) amide on the cytoplasmic Ca(2+)-concentration in rat islet cells.

Abstract

Glucagon like peptide-1(7-36) amide (GLP-1(7-36)amide) stimulates both insulin secretion and the efflux of 45Ca2+ from 45Ca(2+)-preloaded rat islets in a Na(+)-dependent manner. This indicates that the peptide stimulates insulin secretion by Na(+)-dependently increasing the intracellular concentration of Ca2+ ([Ca2+]IC). However, whether GLP-1(7-36)amide… (More)

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