Effects of glucagon and vasopressin on hepatic Ca2+ release.

  title={Effects of glucagon and vasopressin on hepatic Ca2+ release.},
  author={Naomi Kraus-Friedmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 23},
The effects of physiological levels of glucagon on Ca2+ efflux were examined in the perfused rat liver. Two methods were used to estimate Ca2+ efflux: prior labeling of the calcium pools with 45Ca2+ and measurement of perfusate Ca2+ with atomic absorption. According to both methods, glucagon administration at the physiological level evoked Ca2+ release. The released Ca2+ originated mostly from a carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP)-depletable pool and also from an FCCP… CONTINUE READING

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