Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type 2 diabetes mellitus.

@article{Kabadi2004EffectsOG,
  title={Effects of glimepiride on insulin secretion and sensitivity in patients with recently diagnosed type 2 diabetes mellitus.},
  author={M. Kabadi and U. Kabadi},
  journal={Clinical therapeutics},
  year={2004},
  volume={26 1},
  pages={
          63-9
        }
}
BACKGROUND The exact mechanism of the efficacy of glimepiride in the achievement of glycemic control has not yet been clearly defined. OBJECTIVE This study was conducted to examine the influence of glimepiride on insulin secretion and sensitivity in patients with type 2 diabetes mellitus (DM) of recent onset. METHODS This 24-week, open-label, controlled trial was conducted at the Division of Endocrinology and Metabolism, Veterans Affairs Medical Center (Phoenix, Arizona). Study participants… Expand
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TLDR
Glimepiride and metformin are effective individually in achieving a glycemic goal with a less daily insulin dose, weight gain, and hypoglycemic episodes in comparison to insulin monotherapy in subjects with type 2 diabetes mellitus with further marked reduction in these parameters when used concurrently. Expand
Efficacy and safety of glimepiride as initial treatment in Chinese patients with Type 2 diabetes mellitus
TLDR
Glimepiride treatment as initial mono-therapy could effectively improve blood glucose control in type 2 diabetic patients, with a favorable safety profile. Expand
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TLDR
Glimepiride monotherapy in the present observational study in daily practice for 3 months was shown to be effective in reducing HbA1c and FBG levels, especially in treatment naive patients, and was associated with weight gain. Expand
Comparative efficacy between glimepiride and metformin in preventing progression of prediabetes to type 2 diabetes
TLDR
Comparison efficacy of glimepiride and metformin in progression of prediabetes to type 2 diabetes in subjects with predi diabetes is examined. Expand
Effects of Glimepiride on metabolic parameters and cardiovascular risk factors in patients with newly diagnosed type 2 diabetes mellitus.
TLDR
Glimepiride can rapidly and stably improve glycemic control and lipoprotein metabolism, significantly alleviate insulin resistance and enhance fibrinolytic activity. Expand
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TLDR
Decline in β-cell function in morbidly obese T2DM may not be progressive and is reversible on improving insulin sensitivity and on eliminating the inhibition by exogenous insulin. Expand
Myths and Facts About Glimepiride
Glimepiride is either used as monotherapy or in combination with metformin or insulin for effective control of hyperglycemia in people with type 2 diabetes mellitus. In spite of its effectiveExpand
Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus.
TLDR
Rg, Gm and Gli can all decrease blood glucose effectively in newly diagnosed T2DM patients, while Rg performs outstandingly in the aspects of improving early-phase insulin secretion, glucose excursion, postprandial lipids and 8-iso PGF(2alpha). Expand
Modulation of the Antidiabetic Effect of Glimepiride by Diazepam in Diabetic Rats
TLDR
Diazepam increased the antidiabetic and the antioxidant actions of glimepiride which may be of considerable value in the treatment of diabetes mellitus where both reduction of associated anxiety and tight glycemic control are needed. Expand
Effect of genetic polymorphisms on the pharmacokinetics and efficacy of glimepiride in a Korean population.
TLDR
Knowing of seven single nucleotide polymorphisms in four candidate genes with the efficacy of glimepiride provides no clinical useful information for the pharmacogenetic therapeutic approach for Korean patients with type 2 diabetes. Expand
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Improvement in lipids with glimepiride in type 2 diabetes mellitus
TLDR
This study documents that glimepiride is effective not only in improving glycemic control, but it also induces a reversal of adverse lipid patterns noted in subjects with type 2 diabetes mellitus. Expand
Glimepiride improves both first and second phases of insulin secretion in type 2 diabetes.
TLDR
It is demonstrated that glimepiride improves both first and second phases of insulin secretion, but not insulin sensitivity, in individuals with type 2 diabetes. Expand
Influence of gliclazide on glucose-stimulated insulin release in man.
TLDR
The influence of the SU gliclazide on glucose-stimulated insulin release in eight healthy male volunteers was assessed and no difference was observed in plasma C-peptide response at the end of the 32-mmol/L hyperglycemic glucose clamps. Expand
Effect of glipizide GITS on insulin sensitivity, glycemic indices, and abdominal fat composition in NIDDM
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Glipizide GITS significantly improved meal tolerance, reduced glycated blood proteins, and increased insulin sensitivity in vivo, and there was no significant change in abdominal fat distribution during the trial. Expand
The Acute and Chronic Effects of Sulfonylurea Therapy in Type II Diabetic Subjects
TLDR
Glyburide therapy increases endogenous insulin secretion, increases adipocyte insulin binding after 18, but not 3, mo of therapy, enhances peripheral insulin action by acting primarily at a post-receptor site, and reduces basal hepatic glucose output. Expand
A Placebo‐Controlled, Randomized Study of Glimepiride in Patients with Type 2 Diabetes Mellitus for Whom Diet Therapy is Unsuccessful
TLDR
Glimepiride is safe and effective for treatment of patients with type 2 diabetes for whom diet therapy is unsuccessful and improved postprandial insulin and C‐peptide responses without producing clinically meaningful increases in fasting insulin or C‐ peptide levels. Expand
Acute effect of glimepiride on insulin-stimulated glucose metabolism in glucose-tolerant insulin-resistant offspring of patients with type 2 diabetes.
TLDR
Glimepiride improves peripheral glucose uptake and decreases endogenous glucose production independent of its insulin secretagogue action is shown, however, too small to be considered therapeutically beneficial for the individual patient. Expand
Different Effects of Glyburide and Glipizide on Insulin Secretion and Hepatic Glucose Production in Normal and NIDDM Subjects
TLDR
The results indicate that the acute administration of GB and GZ to NIDDM subjects has quantitatively different results on hepatic glucose production and acute plasma insulin response to hyperglycemia, challenging the concept that sulfonylurea agents, when given acutely, potentiate glucose-stimulated insulin secretion. Expand
Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects.
TLDR
Glimepiride remarkably improved insulin resistance, suggested by a significant reduction in HOMA-IR, an increase in MCR-g, and a Reduction in HbA(1c) without changing extrapancreatic beta-cell function and urine CPR. Expand
The Effect of Glimepiride on Pancreatic β-Cell Function Under Hyperglycaemic Clamp and Hyperinsulinaemic, Euglycaemic Clamp Conditions in Non-Insulin-Dependent Diabetes Mellitus
: The comparative effects of glimepiride (Amaryl; HOE 490) and glibenclamide on insulin and glucose metabolism under hyperglycaemic and hyperinsulinaemic, euglycaemic clamp conditions were studied inExpand
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