Effects of ginkgo biloba on in vitro osteoblast cells and ovariectomized rat osteoclast cells

@article{Oh2008EffectsOG,
  title={Effects of ginkgo biloba on in vitro osteoblast cells and ovariectomized rat osteoclast cells},
  author={Seung Min Oh and Ha Ryong Kim and Kyu Hyuck Chung},
  journal={Archives of Pharmacal Research},
  year={2008},
  volume={31},
  pages={216-224}
}
Ginkgo biloba extract (GBE) has a selective estrogen receptor modulator (SERM)-like biphasic effect on estrogen, and could be a potential alternative to hormone replacement therapy (HRT). Here, we investigated whether GBE can ameliorate estrogen-depleted osteoporosis in in vitro osteoblast cells and in estrogen-deprived ovariectomized (OVX) rats, a classical animal model for postmenopausal osteoporosis. GBE (50–150 μg/mL) significantly increased ALP (Alkaline phosphatase) activity of osteoblast… Expand
Ginkgo biloba extract (EGb761) did not express estrogenic activity in an immature rat uterotrophic assay
TLDR
Evaluated agonistic and antagonistic activities of EGb761 using a uterotrophic assay in immature female rats suggested EGb 761 has no agonistic/antagonistic effects in utero. Expand
The Effect of the Ginkgo biloba Extract in the Expression of Bax, Bcl‐2 and Bone Mineral Content of Wistar Rats with Glucocorticoid‐Induced Osteoporosis
TLDR
The EGb improved the Bcl‐2 and reduced the Bax expression by osteoblasts in the mandibular alveolar bone and recovered the mineral content in the tibia of rats with glucocorticoid‐induced‐osteoporosis. Expand
Simvastatin induces estrogen receptor-alpha expression in bone, restores bone loss, and decreases ERα expression and uterine wet weight in ovariectomized rats
TLDR
It is suggested that simvastatin exert opposing modulatory effects on ERα expression on bone and uterus in ovariectomized rats, inducing ER α expression and synergy with estrogen to perform anabolic effects on the bones while decreasing E2 efficacy and uterine wet weight. Expand
The Inhibitory Effects of the Standardized Extracts of Ginkgo biloba on Aromatase Activity in JEG‐3 Human Choriocarcinoma Cells
TLDR
Ginkgo biloba could act as an AI at both the enzyme and transcriptional levels, and aromatase activities were inhibited by EGb both in JEG‐3 cells and in recombinant CYP19 microsomes. Expand
Ginkgo biloba extract EGb 761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer.
  • Y. Park, H. Ahn, Ha Ryong Kim, K. Chung, S. Oh
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2016
TLDR
Results indicated that EGb 761 inhibited aromatase and exerted antitumor effects on breast cancer cells both in vitro and in–vivo, and suggest that EG b761 may be a useful aromat enzyme inhibitor for the treatment for estrogen-sensitive breast cancer. Expand
Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing.
TLDR
The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry and restored the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. Expand
Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis.
TLDR
It is demonstrated that three flavonoid synergistically inhibit estrogen biosynthesis through aromatase inhibition, decrease CYP19 mRNA, and induce transcriptional suppression, which support the usefulness of flavonoids in adjuvant therapy for breast cancer by reducing estrogen levels with reduced adverse effects due to estrogen depletion. Expand
The effects of the standardized extracts of Ginkgo biloba on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells
TLDR
It is suggested that EGb761 could regulate steroidogenesis-related genes such as CYP19 and 17 β-HSD1, and lead to a decrease in 17β-estradiol and testosterone. Expand
Radiographic evidence of mandibular osteoporosis improvement in Wistar rats treated with Ginkgo biloba
TLDR
The EGb recovered the periodontal bone support and increased the mandibular cortical thickness, suggesting that the EGb may be effective in the treatment of osteoporosis. Expand
Effects of Flavonoids from Gingko Biloba Extracts on Estrogen Biosynthesis
Since estrogen is a key hormone that stimulates cancer growth during the initiation and promotion stages, regulating estrogen is important in the treatment of hormone-dependent breast cancer (YagerExpand
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  • S. Oh, K. Chung
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2006
TLDR
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