Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.

@article{Chen2005EffectsOG,
  title={Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.},
  author={Biyi Chen and Jing-xia Cai and Long-Sheng Song and Xiaoqing Wang and Zhihe Chen},
  journal={Life sciences},
  year={2005},
  volume={76 10},
  pages={
          1111-21
        }
}
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The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms
TLDR
This study reviews 19 natural drug therapies, with 18 active ingredient therapies, such as alkaloids, flavonoids, saponins, quinones, and terpenes, and two kinds of traditional Chinese medicine compound, all of which have been studied and reported as having antiarrhythmic effects.
Ginkgo biloba for prevention of acute mountain sickness: does it work?
TLDR
Overall, the literature suggests that due to the complexity of GBE the standardization of the product is inadequate, which likely explains the disparate clinical results.
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References

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Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.
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  • Biology, Medicine
    Arzneimittel-Forschung
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TLDR
Results indicate that even after acute administrations, GBE and bilobalide produced active actions on the APD and the ionic currents in cardiomyocytes, although each chemical exhibited the responses in opposite directions.
Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators.
TLDR
It is demonstrated that the constituents of Ginkgo biloba leaf extract, ginkgolides A, B, C and J are also effective blockers of glycine-activated chloride channels in the hippocampal neurons of rat.
Electrophysiological effects of protopine in cardiac myocytes: inhibition of multiple cation channel currents
TLDR
Protopine is not a selective Ca2+ channel antagonist, rather, it acts as a promiscuous inhibitor of cation channel currents including ICa,L, Ik, IK1 as well as INa, which may provide some mechanistic explanations for the therapeutic actions of Pro in the heart.
The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium
TLDR
It is concluded that at least part of the quercetin‐induced Cl− secretion can be explained by an activation of basolateral K+ channels.
Hemodynamic and Electrocardiographic Effects of Short-Term Ginkgo Biloba
TLDR
Commonly used doses of Ginkgo biloba do not have any immediate or short-term effects on blood pressure, heart rate, or electrocardiographic variables in young, healthy volunteers.
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