Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia

@article{Yan2008EffectsOG,
  title={Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia},
  author={Fuling Yan and Ying Zheng and Feng-di Zhao},
  journal={Acta Neuropathologica},
  year={2008},
  volume={116},
  pages={529-535}
}
Alzheimer’s disease (AD), characterized by accumulation of amyloid-beta protein (Aβ) in brain parenchyma, is closely associated with brain ischemia. Decreased clearance of Aβ from brain is the main cause of Aβ accumulation in sporadic AD. However, the mechanisms underlying ischemia-mediated AD pathogenesis remain unclear. The receptor for advanced end glycation products (RAGE) and low-density lipoprotein receptor-related protein-1 (LRP-1) expressed at blood brain barrier (BBB) are actively… CONTINUE READING

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