Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits.

@article{Alt2011EffectsOG,
  title={Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits.},
  author={Volker Alt and Achim Bitschnau and Felicitas B{\"o}hner and Katharina Elisabeth Heerich and Erika Magesin and Andreas Sewing and Theodoros Pavlidis and Gabor Szalay and Christian Heiss and Ulrich Thormann and Sonja Hartmann and Wolfgang Pabst and Sabine Wenisch and Reinhard Schnettler},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 3},
  pages={1274-80}
}
Antimicrobial coatings are of interest as a means to improve infection prophylaxis in cementless joint arthroplasty. However, those coatings must not interfere with the essential bony integration of the implants. Gentamicin-hydroxyapatite (gentamicin-HA) and gentamicin-RGD (arginine-glycine-aspartate)-HA coatings have recently been shown to significantly reduce infection rates in a rabbit infection prophylaxis model. The purpose of the current study was to investigate the in vitro elution… CONTINUE READING
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