Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats

@article{Dai2007EffectsOG,
  title={Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats},
  author={Ru-chun Dai and Yulin Ma and Zhifeng Sheng and Yan Jin and Yuhai Zhang and Lingna Fang and Huijie Fan and Eryuan Liao},
  journal={Journal of Bone and Mineral Metabolism},
  year={2007},
  volume={26},
  pages={342-349}
}
Until now, the effects of phytoestrogen on bone in both women and ovarian hormone-deficient animal models of osteoporosis have remained uncertain. We have aimed here to investigate the effect of genistein (GEN) on trabecular bone quality in ovariectomized (OVX) rats. Forty 7-month-old female Sprague-Dawley rats were randomly divided into the following four groups: OVX, sham-operated (SHAM), treated with 17β-estradiol (EST, 10 μg·kg−1·day−1), and GEN (5 mg·kg−1·day−1). At 15 weeks postoperation… CONTINUE READING
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Protective effects of sodium daidzein sulfonate on trabecular bone in ovariectomized rats

  • P Ren, H Ji, Q Sao, X Chen, J Han, Y Sun
  • Pharmacology
  • 2007

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