Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells.

@article{Shieh2010EffectsOG,
  title={Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells.},
  author={Dar-Bin Shieh and Rui-You Li and Jiuan-Miaw Liao and Gin-Den Chen and Y. Liou},
  journal={Journal of cellular physiology},
  year={2010},
  volume={223 2},
  pages={
          423-34
        }
}
This study was performed to define the roles of actin-binding proteins in the regulation of actin filament assembly associated with cellular signal transduction pathways in stromal cell proliferation. Genistein, a tyrosine protein kinase inhibitor, decreased the intracellular Ca(2+) and attenuated cell proliferation and DNA synthesis through the beta-catenin and cyclin D1 pathway in human umbilical CD105-positive cells. Immunoprecipitation studies using anti-beta-actin antibody revealed that… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

  • The Journal of biological chemistry
  • 1987
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cyclin D 1 and breast cancer

DA Ryley, HH Wu, +3 authors MR Gray
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A new model for asymmetric spindle positioning in mouse oocytes

M Secco, E Zucconi, +7 authors M Zatz
  • Curr Biol
  • 2008
VIEW 1 EXCERPT