Effects of genetic variations on microRNA: target interactions

@inproceedings{Liu2014EffectsOG,
  title={Effects of genetic variations on microRNA: target interactions},
  author={Chaochun Liu and William A. Rennie and C. Steven Carmack and Shaveta Kanoria and Jijun Cheng and Jun Lu and Ye Ding},
  booktitle={Nucleic acids research},
  year={2014}
}
Genetic variations within microRNA (miRNA) binding sites can affect miRNA-mediated gene regulation, which may lead to phenotypes and diseases. We perform a transcriptome-scale analysis of genetic variants and miRNA:target interactions identified by CLASH. This analysis reveals that rare variants tend to reside in CDSs, whereas common variants tend to reside in the 3' UTRs. miRNA binding sites are more likely to reside within those targets in the transcriptome with lower variant densities… CONTINUE READING

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Genetic variations within microRNA ( miRNA ) binding sites can affect miRNA - mediated gene regulation , which may lead to phenotypes and diseases .
Genetic variations within microRNA ( miRNA ) binding sites can affect miRNA - mediated gene regulation , which may lead to phenotypes and diseases .
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