Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.

  title={Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.},
  author={Duanpen Sandee and Kari M. Morrissey and Vishal Agrawal and Harrison K Tam and Melissa A Kramer and Timothy S. Tracy and Kathleen M. Giacomini and Walter Miller},
  journal={Pharmacogenetics and genomics},
  volume={20 11},
OBJECTIVES Cytochrome P450 (P450) oxidoreductase (POR) donates electrons to all microsomal cytochrome P450s, including drug-metabolizing and steroidogenic enzymes. Severe POR mutations cause skeletal malformations and disordered steroidogenesis. The POR polymorphism A503V is found on approximately 28% of human alleles and decreases activities of CYP3A4 and steroidogenic CYP17, but not the activities of steroidogenic CYP21 or drug-metabolizing CYP1A2 and CYP2C19. CYP2D6 metabolizes about 25% of… CONTINUE READING
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