Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control.

@article{Asamoto2002EffectsOG,
  title={Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control.},
  author={Makoto Asamoto and Naomi Hokaiwado and Young-man Cho and Tomoyuki Shirai},
  journal={Carcinogenesis},
  year={2002},
  volume={23 3},
  pages={463-7}
}
The incidence of prostate carcinomas in African-American men is greater than in white men, indicating genetic factors are involved in risk of this neoplasia. Recently, we have developed a transgenic rat model of prostate cancer, featuring development of malignancies within 15 weeks of age at very high incidence. Male transgenic rats with a Sprague-Dawley genetic background were mated with wild-type females of F344, Wistar and ACI strains. F1 male transgenic hybrids with female Wistar and ACI… CONTINUE READING

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