Effects of general anaesthetics on ligand-gated ion channels.

@article{Daniels1993EffectsOG,
  title={Effects of general anaesthetics on ligand-gated ion channels.},
  author={S. Daniels and Elspeth B. Smith},
  journal={British journal of anaesthesia},
  year={1993},
  volume={71 1},
  pages={
          59-64
        }
}
The site at which anaesthetics act within the central nervous system (CNS) has been the subject of research for almost 100 years. Most success has been obtained in defining the physical nature of the site [70]. For example, the well established correlation of anaesthetic potency to fat solubility indicates that the site of action is hydrophobic. Research using anaesthetics with unusual solubility properties (sulphur hexafluoride and carbon tetrafluoride) failed to provide support for the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 78 REFERENCES

Actions of volatile anesthetics and alcohols on cholinergic receptor channels.

  • Annals of the New York Academy of Sciences
  • 1991
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

The nicotinic acetylcholine receptor in its membrane environment.

  • Annals of the New York Academy of Sciences
  • 1991
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The effect of hydrostatic pressure on glycine receptors expressed in Xenopus oocytes

CJ Shelton, MG Doyle, S Daniels, EB. Smith
  • Journal of Physiology {London)
  • 1992
VIEW 1 EXCERPT