Effects of gender difference on cardiac myocyte dysfunction in streptozotocin-induced diabetic rats

@article{Ding2007EffectsOG,
  title={Effects of gender difference on cardiac myocyte dysfunction in streptozotocin-induced diabetic rats},
  author={Yanfeng Ding and Ruijiao Zou and Robert L. Judd and Juming Zhong},
  journal={Endocrine},
  year={2007},
  volume={29},
  pages={135-141}
}
The main characteristics of type 1 diabetic cardiomyopathy include depressed contractility and altered electrophysiological properties in ventricular myocytes. The goal of the present study was to determine the potential influence of gender in the diabetes-induced pathogenesis of ventricular myocyte function. Diabetes in both male and female rats was induced by a single intravenous injection of streptozotocin (STZ). Diabetic rats exhibited hyperglycemia and reduced body weight gain in both male… Expand
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Methods Citations
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10 Citations

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Citation Type

Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic rats
TLDR
The data suggest that altered electrophysiological properties in ventricular myocytes were largely resulted from augmented ET-1 system in diabetic animals, and bosentan treatment had no effect on L-type Ca2+ currents in both control and diabetic myocytes. Expand
Morphology and contractility of cardiac myocytes in early stages of streptozotocin-induced diabetes mellitus in rats.
TLDR
Impaired calcium handling is one of the factors that contributes to the observed decrease in myocyte shortening during early stages of streptozotocin-induced diabetes in rats, which suggests disproportional reorganization of the structure of the heart tissue during short-term diabetes. Expand
DEFECTIVE INTRACELLULAR Ca2+ HOMEOSTASIS CONTRIBUTES TO MYOCYTE DYSFUNCTION DURING VENTRICULAR REMODELLING INDUCED BY CHRONIC VOLUME OVERLOAD IN RATS
TLDR
The data indicate that the transition to heart failure secondary to chronic volume overload is related to depressed myocyte contractility secondary to altered intracellular Ca2+ homeostasis. Expand
Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus.
TLDR
The case for experimental interrogation of sex differences, and of sex steroid influences in the aetiology of diabetic cardiomyopathy, is particularly compelling-providing incentive for future investigation with ultimate therapeutic potential. Expand
High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes.
TLDR
Significantly, NRVM synthesized and retained ANG II intracellularly, which redistributed to the nucleus under high-glucose conditions, suggesting a role for an intracrine mechanism in diabetic conditions. Expand
Enhanced stem cell‐derived cardiomyocyte differentiation in suspension culture by delivery of nitric oxide using S‐nitrosocysteine
TLDR
By enabling maintenance of spontaneous contraction in suspension culture and progressing electrophysiological function of resulting SC‐CMs toward a more mature phenotype, long‐term application of S‐nitrosocysteine was shown to be beneficial during cardiac differentiation. Expand
Sex and Gender Differences in Cardiovascular Disease
TLDR
Gender differences play a major role in the manifestation and outcomes of cardiovascular disease, and its most frequent causes such as hypertension, myocardial infarction, coronary artery disease, on cardiomyopathies and atrial fibrillation. Expand
A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy
TLDR
The development of cardiac dysfunction, the mechanisms underlying diabetic cardiomyopathy, diagnostic methods, and treatment options are discussed. Expand
Does garlic have a role as an antidiabetic agent?
TLDR
Evidence suggests that garlic's antioxidative, antiinflammatory, and antiglycative properties are responsible for garlic's role in preventing diabetes progression and the development of diabetes-related complications. Expand
The effect of hexarelin in streptozotocin (STZ)-induced rat model through protective actions on islet beta cells and cardiomyocytes

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