Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics.

@article{Lane1999EffectsOG,
  title={Effects of gender and age on plasma levels of clozapine and its metabolites: analyzed by critical statistics.},
  author={H Y Lane and Y Catherine Chang and W- H Chang and Shih-Ku Lin and Yi T. Tseng and Michael W. Jann},
  journal={The Journal of clinical psychiatry},
  year={1999},
  volume={60 1},
  pages={36-40}
}
BACKGROUND Previous reports concerning the effects of gender and age on steady-state plasma concentrations of clozapine and its major metabolites, norclozapine and clozapine-N-oxide, have been controversial. Since the frequency distribution of the plasma levels is asymmetrical and skewed to the right, the statistical methods (such as analysis of variance and regression analysis) used earlier are actually inappropriate for analyzing the effects of the variables on the concentrations and might… CONTINUE READING

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