• DOI:10.1046/j.1365-2982.1997.d01-59.x
Corpus ID: 31858033

Effects of gastrin‐releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro

@article{Vadokas1997EffectsOG,
  title={Effects of gastrin‐releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro},
  author={B. Vadokas and F. E. L{\"u}dtke and G. Lepsien and K. Golenhofen and K. Mandrek},
  journal={Neurogastroenterology & Motility},
  year={1997},
  volume={9}
}

• B. Vadokas, F. E. Lüdtke, +2 authors K. Mandrek
• Published 1997
• Biology, Medicine
• Neurogastroenterology & Motility

Mechanical activity was recorded in muscle preparations isolated from the human ileocaecal region. Gastrin‐releasing peptide (GRP, 10−9− 10−7 mol L−1) produced two types of response in the different muscle layers. Longitudinally cut strips showed a concentration‐dependent increase in the rhythmic activity, whereas the circularly orientated layers generally reacted with a small decrease in tone. These effects could not be influenced by blockade of adrenergic or cholinergic receptors or nerve… Expand

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