Effects of gastrin‐releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro
@article{Vadokas1997EffectsOG, title={Effects of gastrin‐releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro}, author={B. Vadokas and F. E. L{\"u}dtke and G. Lepsien and K. Golenhofen and K. Mandrek}, journal={Neurogastroenterology & Motility}, year={1997}, volume={9} }
Mechanical activity was recorded in muscle preparations isolated from the human ileocaecal region. Gastrin‐releasing peptide (GRP, 10−9− 10−7 mol L−1) produced two types of response in the different muscle layers. Longitudinally cut strips showed a concentration‐dependent increase in the rhythmic activity, whereas the circularly orientated layers generally reacted with a small decrease in tone. These effects could not be influenced by blockade of adrenergic or cholinergic receptors or nerve… Expand
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References
SHOWING 1-10 OF 23 REFERENCES
Contractile action of gastrin-releasing peptide on isolated preparations of human gastroduodenal muscle.
- Medicine
- Digestive diseases
- 1991
- 6
The direct contractile effect of gastrin releasing peptide on isolated gastric smooth muscle cells of the guinea pig.
- Biology, Medicine
- Life sciences
- 1991
- 2
Bombesin--the most stimulating peptide of human gastric smooth muscle.
- Medicine
- Digestive diseases
- 1991
- 4
Characterization of bombesin effects on canine gastric muscle.
- Biology, Medicine
- The American journal of physiology
- 1982
- 51
Control of the human ileocaecal junction: an in vitro analysis of adrenergic and non-adrenergic non-cholinergic mechanisms.
- Biology, Medicine
- Digestion
- 1993
- 17
Inhibitory effects of gastrin releasing peptide on gastric emptying in rats
- Chemistry, Medicine
- Regulatory Peptides
- 1996
- 20
Perinatal changes in bombesin-stimulated muscle contraction in rabbit stomach and colon.
- Biology, Medicine
- Gastroenterology
- 1991
- 4
Phasic and tonic contraction processes in the gastrointestinal tract.
- Medicine
- Digestive diseases
- 1991
- 18
The contractile effect of bombesin, gastrin releasing peptide and various fragments in the rat stomach strip.
- Biology, Medicine
- European journal of pharmacology
- 1984
- 47
Innervation of the muscularis mucosae of canine proximal colon.
- Medicine
- The Journal of physiology
- 1984
- 54