Effects of gamma-aminobutyric acid and glycine on synaptic excitability of neurones in the solitary tract nucleus.

@article{Feldman1991EffectsOG,
  title={Effects of gamma-aminobutyric acid and glycine on synaptic excitability of neurones in the solitary tract nucleus.},
  author={Peter D. Feldman and Robert B Felder},
  journal={Neuropharmacology},
  year={1991},
  volume={30 3},
  pages={225-36}
}
In the solitary tract nucleus, neuronal responsiveness to synaptic input from peripheral afferent fibres has been found to decrease as the frequency of that input is increased. The present study investigated the possibility that glycine and gamma-aminobutyric acid (GABA) are (1) involved in this phenomenon of "frequency-dependent inhibition" or (2) capable of otherwise modifying neuronal responsiveness to synaptic input. In 32 of 57 neurones, application of glycine reduced responsiveness to… CONTINUE READING