Effects of galactose feeding on aldose reductase gene expression.

  title={Effects of galactose feeding on aldose reductase gene expression.},
  author={Rebekah R Wu and Paul A. Lyons and Aiguo Wang and Amanda Sainsbury and S Chung and T Norman Palmer},
  journal={The Journal of clinical investigation},
  volume={92 1},
Aldose reductase (AR) is implicated in the pathogenesis of the diabetic complications and osmotic cataract. AR has been identified as an osmoregulatory protein, at least in the renal medulla. An outstanding question relates to the response of AR gene expression to diet-induced galactosemia in extrarenal tissues. This paper shows that AR gene expression in different tissues is regulated by a complex multifactorial mechanism. Galactose feeding in the rat is associated with a complex and, on… CONTINUE READING