Effects of gadolinium-based magnetic resonance imaging contrast agents on human skin in organ culture and human skin fibroblasts.

@article{Varani2009EffectsOG,
  title={Effects of gadolinium-based magnetic resonance imaging contrast agents on human skin in organ culture and human skin fibroblasts.},
  author={James Varani and M Dasilva and Roscoe L. Warner and Monica O'Brien Deming and Adam G. Barron and Kent J. Johnson and Richard D. Swartz},
  journal={Investigative radiology},
  year={2009},
  volume={44 2},
  pages={74-81}
}
OBJECTIVE Nephrogenic systemic fibrosis (NSF) is a clinical syndrome linked with exposure in renal failure patients to gadolinium-based magnetic resonance imaging contrast agents (GBCAs). The pathogenesis of the disease is largely unknown. The present study addresses potential pathophysiological mechanisms. MATERIALS AND METHODS Here, we have examined human skin in organ culture and human dermal fibroblasts in monolayer culture for responses to GBCA stimulation. RESULTS Treatment of normal… CONTINUE READING