Effects of fumonisin B1 in pregnant rats. Part 2.

  title={Effects of fumonisin B1 in pregnant rats. Part 2.},
  author={Thomas F X Collins and Robert L. Sprando and Thomas N Black and Mary E Shackelford and J B L{\'a}borde and Deborah K. Hansen and Robert M Eppley and Mary W. Trucksess and Paul C. Howard and Mark A. Bryant and Dennis I Ruggles and Nicholas Olejnik and James I Rorie},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={36 8},
The developmental toxicity of purified fumonisin B1 (FB1), a mycotoxin from the common corn fungus Fusarium moniliforme, was examined in Charles River rats. Pregnant rats were dosed orally on gestation days 3-16 at 0, 6.25, 12.5, 25 or 50 mg FB1/kg body weight/day. FB1 was not teratogenic at the doses tested. At 50 mg/kg, maternal toxicity (inappetence, emaciation, lethargy, death, resorption of entire litters) and foetal toxicity (increased number of late deaths, decreased foetal body weight… CONTINUE READING