Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia.

@article{Bickler1996EffectsOF,
  title={Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia.},
  author={Philip E. Bickler and Leslie Thomas Buck},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 4},
  pages={1463-8}
}
Fructose-1,6-bisphosphate (FBP), an intermediate of glucose metabolism, is neuroprotective in brain hypoxia or ischemia. Because the mechanisms for this protection are not clear, we examined the effects of FBP on two important events in brain ischemia, i.e., loss of ATP and release of the excitatory neurotransmitter glutamate. Glutamate release from cortical brain slices was measured fluorometrically (glutamate dehydrogenase-catalyzed conversion of glutamate to alpha-ketoglutarate) during… CONTINUE READING
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