Effects of frontal polar cortical ablation and cycloheximide on ethanol tolerance in rats

@article{Leblanc1976EffectsOF,
  title={Effects of frontal polar cortical ablation and cycloheximide on ethanol tolerance in rats},
  author={A. Eugene Leblanc and M. D. Tsutomu Matsunaga and Harold Kalant},
  journal={Pharmacology Biochemistry and Behavior},
  year={1976},
  volume={4},
  pages={175-179}
}
Thirty adult male Wister rats were pretrained to criterion on the moving belt test, and then made tolerant to ethanol by daily administration of increasing doses over a period of 3 weeks. After a one-month recovery period, they were divided into 3 groups, subjected to bilateral frontal polar cortical ablations, sham-operation and no operation respectively. After postoperative recovery, the cycle of ethanol treatment and testing was repeated. Only the lesioned group failed to reacquire tolerance… CONTINUE READING