Effects of frequent marijuana use on brain tissue volume and composition

  title={Effects of frequent marijuana use on brain tissue volume and composition},
  author={R. Block and D. O’Leary and J. Ehrhardt and J. Augustinack and M. Ghoneim and S. Arndt and J. A. Hall},
To investigate CNS effects of frequent marijuana use, brain tissue volume and composition were measured using magnetic resonance imaging (MRI) in 18 current, frequent, young adult marijuana users and 13 comparable, non-using controls. Automated image analysis techniques were used to measure global and regional brain volumes, including, for most regions, separate measures of gray and white matter. The marijuana users showed no evidence of cerebral atrophy or global or regional changes in tissue… Expand
Altered brain tissue composition in heavy marijuana users.
The preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in thebrain. Expand
Cortical thinness and volume differences associated with marijuana abuse in emerging adults.
RFG cortical thinness and smaller thalamic volume in emerging adults is associated with MJ abuse, and combined with growing evidence that the thalamus is neurobiologically perturbed by MJ use, may interfere with their known roles in regulating visuoperceptual and object information processing. Expand
Long-term effects of marijuana use on the brain
The results showed that compared with controls, marijuana users had significantly less bilateral orbitofrontal gyri volume, higher functional connectivity in the orbitof prefrontal cortex (OFC) network, and higher structural connectivity in tracts that innervate the OFC (forceps minor) as measured by fractional anisotropy (FA). Expand
Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults
There is no association between marijuana use and standard volumetric or shape measurements of subcortical structures in structures suggested to be associated with marijuana use, as follows: the nucleus accumbens, amygdala, hippocampus, and cerebellum. Expand
Cannabis Use in Youth is Associated with Limited Alterations in Brain Structure
Structural brain metrics were similar among adolescent and young adult cannabis users and non-users, and data converge with prior large-scale studies suggesting small or limited associations between cannabis use and structural brain measures in youth. Expand
Abnormal cerebellar morphometry in abstinent adolescent marijuana users
Adolescent MJ users demonstrated significantly larger inferior posterior cerebellar vermis volume than controls, above and beyond effects of lifetime alcohol and other drug use, gender, and intracranial volume. Expand
Cannabis use in youth is associated with limited alterations in brain structure
Structural brain metrics were largely similar among adolescent and young adult cannabis users and non-users, and data converge with prior large-scale studies suggesting small or limited associations between cannabis use and structural brain measures in youth. Expand
Recreational marijuana use impacts white matter integrity and subcortical (but not cortical) morphometry
The results indicate that the earlier the age of onset of marijuana use, the lower was white matter coherence and the number of lifetime uses impacted the shape of the amygdala and hippocampus. Expand
Structural MRI Findings in Long-Term Cannabis Users: What Do We Know?
Structural imaging findings suggest that THC exposure does affect brain morphology, especially in medial–temporal regions, and further research is clearly required, particularly given the prevalence of cannabis use worldwide. Expand
Altered prefrontal and insular cortical thickness in adolescent marijuana users
The results suggest that age of regular use may be associated with altered prefrontal cortical gray matter development in adolescents and reduced insular cortical thickness may be a biological marker for increased risk of substance dependence. Expand


The Neuropathology of Alcohol‐specific Brain Damage, or Does Alcohol Damage the Brain?
  • C. Harper
  • Medicine, Psychology
  • Journal of neuropathology and experimental neurology
  • 1998
Dendritic and synaptic changes have been documented in uncomplicated alcoholics and these, together with receptor and transmitter changes, may explain functional changes and cognitive deficits that precede the more severe structural neuronal changes. Expand
Neurological and neuroradiological examination of chronic cannabis smokers
Only the subject with a history of alcoholism showed any abnormal cerebral function on clinical tests or any abnormality in the CT scan, compared with normal controls. Expand
Modifications radiologiques et neurologiques chez les toxicomanes: étude par résonance magnétique
The neurological and Magnetic Resonance Imaging findings in a group of seven drug abuse patients showed areas of demyelination in white matter, which hypothesize that some of the neurologic and psychiatric complications of drug abuse may be due to its effects on the cerebral circulation. Expand
Stroke after heavy cannabis smoking.
Evidence for a hypothalamic site ofaction of clomiphene citrate in women and its relevance to Tourette's syndrome is presented. Expand
Gender differences in mood and anxiety disorders : from bench to bedside
Foreword. Gender differences in neuroimaging. Women, stress, and depression: sex differences in hypothalamic-pituitary-adrenal axis regulation. Modulation of anxiety by reproductive hormones. HormoneExpand
Role of Cannabinoid Receptors in Memory Storage
A possible role for cannabinoid receptors and endogenous cannabinoids may be to regulate the storage (i.e., encoding) of information, as well as the means by which that information is retrieved. Expand
Cannabis and Cognitive Functioning
Cannabis intoxication can produce measurable impairments in concentration and short term memory, difficulties in goal directed activity, slowed reaction times, and altered perceptions of the passage of time. Expand
Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging
Direct and Indirect Radiologic Localization Reference System: Basal Brain Line CA-CP Cerebral Structures in Three-Dimensional Space Practical Examples for the Use of the Atlas in NeuroradiologicExpand
Quick Diagnostic Interview Schedule III-R
  • St. Louis: Washington University School of Medicine,
  • 1991
Manual for School Administrators