Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture.

@article{Sears1993EffectsOF,
  title={Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture.},
  author={Rosa M. Se{\~n}ar{\'i}s and M. D. Lewis and Francisca Lago and Fernando Dom{\'i}nguez and Maurice F. Scanlon and Carlos Di{\'e}guez},
  journal={Journal of molecular endocrinology},
  year={1993},
  volume={10 2},
  pages={
          207-14
        }
}
The effects of free fatty acids on somatostatin secretion, content and mRNA levels in fetal rat hypothalamic and cortical cell cultures were investigated. Somatostatin secretion and content were quantified by radioimmunoassay. Somatostatin mRNA levels were measured by Northern blot hybridization using a cRNA probe. Treatment with either caprylic acid (5 x 10(-3) M) or oleic acid (5 x 10(-5) M) for 90 min inhibited basal somatostatin secretion in both hypothalamic and cortical cell cultures. In… 
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24 Citations

Transforming Growth Factor-βs Inhibit Somatostatin Messenger Ribonucleic Acid Levels and Somatostatin Secretion in Hypothalamic Cells in Culture.

The blockade of synthesis of proteins with either cycloheximide or puromycin for 24 h prevented the inhibitory effect of TGFβ1 on somatostatin mRNA, implying that the reduction of this mRNA by TGF β1 required de novo protein synthesis.

Fatty Acid Regulation of Endocrine Activity

It is clear that the inhibitory influence of NEFA on lipolytic hormones like GH is part of an intricate feedback loop that contributes to metabolic homeostasis.

Free fatty acids exert an inhibitory effect on adrenocorticotropin and cortisol secretion in humans.

It is shown that an LHE-induced increase in FFA levels has an inhibitory effect on spontaneous ACTH and cortisol secretion in humans, which would indicate that the negative influence of FFA on the HPA axis in humans takes place at the suprapituitary level.

Evidence for the involvement of non-androgenic testicular factors in the regulation of hypothalamic somatostatin and GHRH mRNA levels.

Metabolic modulation of the growth hormone-releasing activity of hexarelin in man.

β‐Hydroxybutyric Acid Inhibits Growth Hormone‐Releasing Hormone Synthesis and Secretion Through the GPR109A/Extracellular Signal‐Regulated 1/2 Signalling Pathway in the Hypothalamus

It is suggested that BHBA directly regulates GHRH synthesis and secretion via the GPR109A/ERK1/2 MAPK pathway, and also that Gsh‐1 is essential for this function.

Effects of free fatty acids and acipimox, a lipolysis inhibitor, on the somatotroph responsiveness to GHRH in anorexia nervosa

It is hypothesized that somatotroph cells could be less sensitive to the negative feedback action of FFA in anorexia nervosa.

Long-term administration of acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid in obesity.

  • S. NamLee K. Huh
  • Medicine, Biology
    Metabolism: clinical and experimental
  • 1996

Neuroendocrine control of growth hormone secretion

  • E. Müller
  • Biology, Medicine
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
Better understanding of the function of GHRH, SS, and their receptors and, hence, of neural regulation of GH secretion in health and disease has been achieved with the discovery of a new class of fairly specific, orally active, small peptides and their congeners, the GH-releasing peptides, acting on specific, ubiquitous seven-transmembrane domain receptors, whose natural ligands are not yet known.

Effects of free fatty acids on ACTH and cortisol secretion in anorexia nervosa.

This study showed that corticotroph sensitivity to the inhibitory effect of an FFA load is preserved in patients with anorexia nervosa, in spite of persistent adrenal hyperactivity.