Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture.

@article{Sears1993EffectsOF,
  title={Effects of free fatty acids on somatostatin secretion, content and mRNA levels in cortical and hypothalamic fetal rat neurones in monolayer culture.},
  author={Rosa Mar{\'i}a Se{\~n}ar{\'i}s and M. D. Lewis and Francisca Lago and Fernando Dom{\'i}nguez and Maurice F. Scanlon and Carlos Di{\'e}guez},
  journal={Journal of molecular endocrinology},
  year={1993},
  volume={10 2},
  pages={
          207-14
        }
}
The effects of free fatty acids on somatostatin secretion, content and mRNA levels in fetal rat hypothalamic and cortical cell cultures were investigated. Somatostatin secretion and content were quantified by radioimmunoassay. Somatostatin mRNA levels were measured by Northern blot hybridization using a cRNA probe. Treatment with either caprylic acid (5 x 10(-3) M) or oleic acid (5 x 10(-5) M) for 90 min inhibited basal somatostatin secretion in both hypothalamic and cortical cell cultures. In… 

Fatty Acid Regulation of Endocrine Activity

It is clear that the inhibitory influence of NEFA on lipolytic hormones like GH is part of an intricate feedback loop that contributes to metabolic homeostasis.

Metabolic modulation of the growth hormone-releasing activity of hexarelin in man.

β‐Hydroxybutyric Acid Inhibits Growth Hormone‐Releasing Hormone Synthesis and Secretion Through the GPR109A/Extracellular Signal‐Regulated 1/2 Signalling Pathway in the Hypothalamus

It is suggested that BHBA directly regulates GHRH synthesis and secretion via the GPR109A/ERK1/2 MAPK pathway, and also that Gsh‐1 is essential for this function.

Effects of free fatty acids and acipimox, a lipolysis inhibitor, on the somatotroph responsiveness to GHRH in anorexia nervosa

It is hypothesized that somatotroph cells could be less sensitive to the negative feedback action of FFA in anorexia nervosa.

Acipimox-mediated plasma free fatty acid depression per se stimulates growth hormone (GH) secretion in normal subjects and potentiates the response to other GH-releasing stimuli.

The observation that FFA reduction enhanced in an additive manner the GH secretion elicited by such different stimuli as pyridostigmine, GHRH, and GHRP-6, suggests that F FA suppression acts by a separate mechanism and may have value in the clinical setting for assessing GH reserve.

Neuroendocrine control of growth hormone secretion

  • E. Müller
  • Biology, Medicine
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
Better understanding of the function of GHRH, SS, and their receptors and, hence, of neural regulation of GH secretion in health and disease has been achieved with the discovery of a new class of fairly specific, orally active, small peptides and their congeners, the GH-releasing peptides, acting on specific, ubiquitous seven-transmembrane domain receptors, whose natural ligands are not yet known.

Effects of free fatty acids on ACTH and cortisol secretion in anorexia nervosa.

This study showed that corticotroph sensitivity to the inhibitory effect of an FFA load is preserved in patients with anorexia nervosa, in spite of persistent adrenal hyperactivity.