Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.

@article{Dresner1999EffectsOF,
  title={Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.},
  author={Alex Dresner and Didier Laurent and Melissa Marcucci and M E Griffin and Sylvie Dufour and Gary W. Cline and Lori A. Slezak and Dana K. Andersen and Ripudaman S Hundal and Douglas L. Rothman and Kitt Falk Petersen and Gerald I Shulman},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 2},
  pages={253-9}
}
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were measured using carbon-13 and phosphorous-31 nuclear magnetic resonance spectroscopy in seven healthy subjects before and after a hyperinsulinemic-euglycemic clamp following a five-hour infusion of either lipid/heparin or glycerol/heparin. IRS-1-associated phosphatidylinositol 3-kinase (PI 3-kinase) activity was… CONTINUE READING
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