Effects of formoterol or salmeterol on impulse oscillometry in patients with persistent asthma.

@article{Manoharan2016EffectsOF,
  title={Effects of formoterol or salmeterol on impulse oscillometry in patients with persistent asthma.},
  author={A. J. Jayaprakash Manoharan and Alexander von Wilamowitz-Moellendorff and Ashley E. Morrison and Brian J Lipworth},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={137 3},
  pages={
          727-33.e1
        }
}
BACKGROUND Effects of small-particle long-acting β-agonists on the small airways have been poorly documented. OBJECTIVE We used impulse oscillometry (IOS) to compare single and repeated dosing effects of small- and large-particle long-acting β-agonists. METHODS After a 1- to 2-week run-in period, patients received either 12 μg of small-particle hydrofluoroalkane 134a-formoterol solution or 50 μg of large-particle salmeterol dry powder twice daily plus inhaled corticosteroid for 1 to 2 weeks… CONTINUE READING
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