Effects of food deprivation and high fat diet on opioid receptor binding in rat brain

@article{Tsujii1986EffectsOF,
  title={Effects of food deprivation and high fat diet on opioid receptor binding in rat brain},
  author={Satoru Tsujii and Yoshikatsu Nakai and Junichi Fukata and Toshikiyo Koh and Hiroo Imura},
  journal={Neuroscience Letters},
  year={1986},
  volume={72},
  pages={169-173}
}
The effect of food deprivation for 72 h or a high fat diet on [3H]naloxone binding in the discrete brain regions of male lean Zucker rats was studied. In the midbrain, both treatments increased Bmax for the high-affinity site with no change in Kd. In the cortex, the high fat diet increased Bmax for the high-affinity site. These results suggest that dietary manipulations could produce significant changes in the endogenous opioid system. 

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