Effects of fluvastatin and its major metabolites on low-density lipoprotein oxidation and cholesterol esterification in macrophages.

@article{Tanaka2001EffectsOF,
  title={Effects of fluvastatin and its major metabolites on low-density lipoprotein oxidation and cholesterol esterification in macrophages.},
  author={Koichiro Tanaka and Motohiro Yasuhara and Ken-ichi Suzumura and Hironobu Narita and Takayuki Suzuki},
  journal={Japanese journal of pharmacology},
  year={2001},
  volume={86 3},
  pages={
          289-96
        }
}
We investigated effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and its major metabolites, M2 and M4, on CuSO4-induced low-density lipoprotein (LDL) oxidation and cholesteryl ester accumulation in mouse peritoneal macrophages. All the test compounds inhibited LDL oxidation, and M2 had the most potent effect comparable to vitamin E. When LDL was previously incubated with the test compounds in the presence of CuSO4, the pre-treatment resulted in a… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolemia

  • GL Plosker, AJ Wagstaff
  • Drug 51,
  • 1996

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