Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions.

@article{Gye2003EffectsOF,
  title={Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions.},
  author={Myung Chan Gye and Seiichiroh Ohsako},
  journal={Toxicology letters},
  year={2003},
  volume={143 2},
  pages={217-22}
}
In an effort to uncover the gonadal impairment by the antiandrogen flutamide (FM) in males, the effect of subacute administration of FM on the expression of tight junction (TJ) genes that build the blood-testis barrier (BTB) was investigated in adult rat testis. At 13 weeks old of age male rats were given vehicle (corn oil) or FM (25 mg/kg per day, in corn oil) orally for 6 days. At 8 days (D8) after the first dose, testicular expression of the occludin, claudin-1, and -11 was analyzed by… CONTINUE READING