Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex.

Abstract

The prefrontal cortex is the brain region sensitive to detrimental effects of stress and even mild stress can rapidly impair its function. Aside from initiating proadaptive neuroplastic changes in the prefrontal cortex, chronic stress may also increase vulnerability of cortical neurons to apoptosis. Understanding the mechanism of plasticity and apoptotic… (More)
DOI: 10.1016/j.ejphar.2012.07.042

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