Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study.

@article{Mostert2008EffectsOF,
  title={Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study.},
  author={Jop P. Mostert and Faiza Admiraal-Behloul and Johannes M. Hoogduin and Jasper Luyendijk and D. J. Heersema and Mark A. van Buchem and Jacques de Keyser},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2008},
  volume={79 9},
  pages={1027-31}
}
BACKGROUND Suppressing the antigen-presenting capacity of glial cells could represent a novel way of reducing inflammatory activity in multiple sclerosis (MS). AIMS To evaluate the effects of fluoxetine on new lesion formation in patients with relapsing MS. METHODS In a double-blind, placebo-controlled exploratory study, 40 non-depressed patients with relapsing remitting or relapsing secondary progressive MS were randomised to oral fluoxetine 20 mg or placebo daily for 24 weeks. New lesion… CONTINUE READING