Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.

@article{Dailey1992EffectsOF,
  title={Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats.},
  author={John W. Dailey and Qing-shan Yan and Prasanna K. Mishra and Robert Lee Burger and Phillip C. Jobe},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={260 2},
  pages={
          533-40
        }
}
Fluoxetine, an antidepressant and inhibitor of serotonin reuptake, was evaluated as an anticonvulsant in genetically epilepsy-prone rats (GEPRs) because seizure predisposition in GEPRs is partially dependent on deficits in brain serotonin. Fluoxetine produced dose-dependent reductions in sound-induced convulsion intensity in both moderate seizure GEPRs and severe seizure GEPRs with the peak anticonvulsant effect occurring 4 hr after i.p. administration. A subchronic study in severe seizure… CONTINUE READING

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