Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity

@article{Raz2010EffectsOF,
  title={Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity},
  author={Shlomo Raz and Brett D. Berger},
  journal={Pharmacology Biochemistry and Behavior},
  year={2010},
  volume={96},
  pages={59-66}
}
The present study investigated the effects of the SSRI fluoxetine and the serotonin synthesis blocker--parachlorophenylalanine (PCPA) on morphine self-administration and startle reactivity in rats subjected to social isolation during adulthood. Adult Wistar rats were housed individually or in pairs for 21days. They were treated with fluoxetine, PCPA, or vehicle and tested for their startle response and intake of a morphine solution (0.5mg/ml). Socially restricted rats consumed significantly… CONTINUE READING

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