Effects of fluoxetine and LY 367265 on tolerance to the analgesic effect of morphine in rats.


Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects. The aim of this study was to investigate effects of fluoxetine, a specific serotonin (5-HT) reuptake inhibitor, and LY 367265, an inhibitor of the 5-HT transporter and 5-HT2A receptor antagonist, on tolerance induced to… (More)
DOI: 10.1556/APhysiol.98.2011.2.12


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