Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade.

@article{Liu2010EffectsOF,
  title={Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade.},
  author={Chunsheng Liu and Xiaowei Zhang and Hong Chang and Paul D. A. Jones and Steve B. Wiseman and Jonathan E. Naile and Markus Hecker and John Paul Giesy and Bingsheng Zhou},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={247 3},
  pages={222-8}
}
Previous studies have demonstrated that perfluorinated chemicals (PFCs) can affect reproduction by disruption of steroidogenesis in experimental animals. However, the underlying mechanism(s) of this disruption remain unknown. Here we investigated the effects and mechanisms of action of 1H, 1H, 2H, 2H-perfluoro-decan-1-ol (8:2 FTOH) on steroidogenesis using a human adrenocortical carcinoma cell line (H295R) as a model. H295R cells were exposed to 0, 7.4, 22.2 or 66.6 microM 8:2 FTOH for 24h and… CONTINUE READING

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