Effects of fluoroquinolones on HERG currents.

  title={Effects of fluoroquinolones on HERG currents.},
  author={Ulrike Bischoff and C. Schmidt and Rainer Netzer and Olaf Pongs},
  journal={European journal of pharmacology},
  volume={406 3},
We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath application of sparfloxacin, moxifloxacin and… CONTINUE READING