Effects of fluid shear stress on bone cells.

@article{Williams1994EffectsOF,
  title={Effects of fluid shear stress on bone cells.},
  author={J L Williams and Joseph P. Iannotti and Andr{\'e}s Ham and Jill S Bleuit and Jwo Hua Chen},
  journal={Biorheology},
  year={1994},
  volume={31 2},
  pages={
          163-70
        }
}
Neonatal rat calvarial cells (osteoblast-enriched) were cultured in monolayer on glass slides and subjected to a step increase in shear stress ranging from 3 to 60 dyne/cm2 in a laminar flow chamber. The level of intracellular free calcium ion concentration was monitored using Fura-2 fluorescence during the application of stress. Application of a step increase in stress resulted in a transient increase in calcium starting about 10-20 s after turning on the pump, reaching a peak in about 35 s… CONTINUE READING

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