Effects of fluid shear stress on adventitial fibroblast migration: implications for flow-mediated mechanisms of arterialization and intimal hyperplasia.

@article{Garanich2007EffectsOF,
  title={Effects of fluid shear stress on adventitial fibroblast migration: implications for flow-mediated mechanisms of arterialization and intimal hyperplasia.},
  author={Jeffrey S. Garanich and Rishi A. Mathura and Zhong-Dong Shi and John M. Tarbell},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 6},
  pages={H3128-35}
}
The involvement of vascular fibroblasts (FBs) and smooth muscle (SM)-like cells in physiological and pathological processes in large vessels (intimal hyperplasia) and microvessels (capillary arterialization), and the realization that these cells are exposed to interstitial flow shear stress (SS), motivate this study of SS on FB migratory activity. Rat adventitial FBs were grown to either 30-50% confluence (subconfluent FBs; SFBs) or full confluence (confluent FBs; CFBs) in culture… CONTINUE READING